{"id":12132,"date":"2023-10-18T13:00:40","date_gmt":"2023-10-18T04:00:40","guid":{"rendered":"http:\/\/aquacurrent.com\/rheuma-net\/securewp\/?page_id=12132"},"modified":"2024-08-09T15:59:43","modified_gmt":"2024-08-09T06:59:43","slug":"aronj","status":"publish","type":"page","link":"https:\/\/www.rheuma-net.or.jp\/rheuma\/rheuma\/complications\/aronj\/","title":{"rendered":"\u984e\u9aa8\u58ca\u6b7b"},"content":{"rendered":"

\u984e\u9aa8\u58ca\u6b7b<\/h2>\n

\u9aa8\u7c97\u9b06\u75c7\u306e\u304a\u85ac\u3092\u670d\u7528\u3059\u308b\u3068\u300c\u984e\uff08\u3042\u3054\uff09\u306e\u9aa8\u304c\u58ca\u6b7b\uff08\u3048\u3057\uff09\u3059\u308b\u300d\u3068\u3044\u3046\u8a71\u3092\u805e\u3044\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u305b\u3093\u304b\uff1f\u3053\u3053\u3067\u306f\u3053\u306e\u984e\u9aa8\u58ca\u6b7b\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n

\n
\n

\u984e\u9aa8\u58ca\u6b7b\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h4>\n<\/dt>\n
\n

\u984e\u9aa8\u58ca\u6b7b\u3068\u306f\u6b63\u78ba\u306b\u306f\u9aa8\u5438\u53ce\u85ac\u95a2\u9023\u984e\u9aa8\u58ca\u6b7b\u3068\u3044\u3044\u3001\u300c\u9aa8\u5438\u53ce\u3092\u6291\u5236\u3059\u308b\u85ac\u5264\u306b\u95a2\u9023\u3057\u3066\u751f\u3058\u308b\u984e\u9aa8\u306e\u58ca\u6b7b\u300d\u306e\u3053\u3068\u3067\u3059\u3002\u82f1\u8a9e\u3067\u306fAnti-resorptive agent-related Osteonecrosis of the Jaw\u3068\u306a\u308b\u306e\u3067\u3001\u201cARONJ\u201d\u3068\u3088\u3070\u308c\u307e\u3059\u3002\u300c\u9aa8\u5438\u53ce\u3092\u6291\u5236\u3059\u308b\u85ac\u5264\u300d\u306f\u9aa8\u7c97\u9b06\u75c7\u306b\u5bfe\u3057\u3066\u3057\u3070\u3057\u3070\u6295\u4e0e\u3055\u308c\u308b\u85ac\u5264\u3067\u3001\u5177\u4f53\u7684\u306b\u306f\u30d3\u30b9\u30db\u30b9\u30db\u30cd\u30fc\u30c8\u88fd\u5264\uff08\u5546\u54c1\u540d\uff1a\u30d5\u30a9\u30b5\u30de\u30c3\u30af\u3001\u30a2\u30af\u30c8\u30cd\u30eb\u3001\u30d9\u30cd\u30c3\u30c8\u3001\u30ea\u30ab\u30eb\u30dc\u30f3\u3001\u30dc\u30ce\u30c6\u30aa\u3001\u30dc\u30f3\u30d3\u30d0\u3001\u30ea\u30af\u30e9\u30b9\u30c8\u306a\u3069\uff09\u3001\u30c7\u30ce\u30b9\u30de\u30d6\uff08\u5546\u54c1\u540d\uff1a\u30d7\u30e9\u30ea\u30a2\uff09\u3068\u30ed\u30e2\u30bd\u30ba\u30de\u30d6\uff08\u5546\u54c1\u540d\uff1a\u30a4\u30d9\u30cb\u30c6\u30a3\uff09\u306e\uff13\u88fd\u5264\u3067\u3059\u3002\u30ed\u30e2\u30bd\u30ba\u30de\u30d6\u306f\u9aa8\u5438\u53ce\u4fc3\u9032\u4f5c\u7528\u3068\u9aa8\u5438\u53ce\u6291\u5236\u4f5c\u7528\u306e\uff12\u3064\u306e\u52b9\u679c\u3092\u6301\u3064\u85ac\u5264\u3067\u306a\u306e\u3067\u3059\u304c\u3001\u3053\u306e\u3046\u3061\u306e\u9aa8\u5438\u53ce\u6291\u5236\u4f5c\u7528\u306b\u3088\u3063\u3066\u984e\u9aa8\u58ca\u6b7b\u304c\u751f\u3058\u3046\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u9aa8\u5438\u53ce\u6291\u5236\u85ac\u4ee5\u5916\u306b\u3082\u3001\u8840\u7ba1\u65b0\u751f\u6291\u5236\u4f5c\u7528\u3092\u6301\u3064\u6297VEGF\uff08\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5897\u6b96\u56e0\u5b50\uff09\u6297\u4f53\u88fd\u5264\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\uff08\u5546\u54c1\u540d\uff1a\u30a2\u30d0\u30b9\u30c1\u30f3\uff09\u306b\u3088\u3063\u3066\u3082\u984e\u9aa8\u58ca\u6b7b\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067\u73fe\u5728\u3067\u306f\u201cARONJ\u201d\u3067\u306f\u306a\u304f\u3001\u3082\u3046\u5c11\u3057\u5e83\u3044\u7bc4\u56f2\u306e\u7528\u8a9e\u3068\u3057\u3066\uff0c\u85ac\u5264\u95a2\u9023\u6027\u984e\u9aa8\u58ca\u6b7bMedication-related Osteonecrosis of the Jaw\uff08MRONJ\uff09\u3068\u547c\u3070\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u3057\u305f\u304c\u3063\u3066\u540c\u3058\u9aa8\u7c97\u9b06\u75c7\u306e\u85ac\u5264\u3067\u3082\u30d3\u30bf\u30df\u30f3D\u88fd\u5264\uff08\u5546\u54c1\u540d\uff1a\u30a2\u30eb\u30d5\u30a1\u30ed\u30fc\u30eb\u3001\u30a8\u30c7\u30a3\u30ed\u30fc\u30eb\u306a\u3069\uff09\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u88fd\u5264\uff08\u5546\u54c1\u540d\uff1a\u30a8\u30d3\u30b9\u30bf\u306a\u3069\uff09\u3001\u30c6\u30ea\u30d1\u30e9\u30c1\u30c9\uff08\u5546\u54c1\u540d\uff1a\u30c6\u30ea\u30dc\u30f3\u30fb\u30d5\u30a9\u30eb\u30c6\u30aa\uff09\u3092\u4f7f\u7528\u3057\u3066\u3082\u984e\u9aa8\u58ca\u6b7b\uff08MRONJ\uff09\u306f\u8d77\u3053\u308a\u307e\u305b\u3093\u3002\u8aa4\u89e3\u306e\u306a\u3044\u3088\u3046\u306b\u8a00\u3044\u63db\u3048\u308b\u3068\u3001\u300c\u30d3\u30bf\u30df\u30f3D\u88fd\u5264\u3092\u670d\u7528\u4e2d\u306b\u4eee\u306b\u984e\u9aa8\u306b\u58ca\u6b7b\u304c\u751f\u3058\u3066\u3082\uff0c\u305d\u308c\u306f\u85ac\u5264\u95a2\u9023\u6027\u984e\u9aa8\u58ca\u6b7b\u3068\u306f\u3088\u3070\u306a\u3044\u300d\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n<\/dd>\n<\/dl>\n

\n
\n

\u30d3\u30b9\u30db\u30b9\u30db\u30cd\u30fc\u30c8\u88fd\u5264\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u3068\u5fc5\u305a\u984e\u9aa8\u58ca\u6b7b\u304c\u8d77\u3053\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/h4>\n<\/dt>\n
\n

\u3000\u30d3\u30b9\u30db\u30b9\u30db\u30cd\u30fc\u30c8\u88fd\u5264\u3092\u670d\u7528\u3057\u3066\u3082\u5fc5\u305a\u984e\u9aa8\u58ca\u6b7b\u3092\u767a\u75c7\u3059\u308b\u8a33\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3044\u304f\u3064\u304b\u306e\u5831\u544a\u304c\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u7d4c\u53e3\u306e\u30d3\u30b9\u30db\u30b9\u30db\u30cd\u30fc\u30c8\u88fd\u5264\u3067\u3042\u308c\u307010\u4e07\u4eba\u5e74\u3042\u305f\u308a1\u4ef6\u7a0b\u5ea6\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u308f\u304b\u308a\u3084\u3059\u304f\u8a00\u3046\u3068\u3001\u300c10\u4e07\u4eba\u306e\u4eba\u304c1\u5e74\u9593\u7d4c\u53e3\u30d3\u30b9\u30db\u30b9\u30db\u30cd\u30fc\u30c8\u3092\u670d\u7528\u3059\u308b\u3068\u3002\u7d041\u540d\u306b\u984e\u9aa8\u58ca\u6b7b\u304c\u751f\u3058\u308b\u300d\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3053\u306e\u6570\u5b57\u3092\u3054\u89a7\u306b\u306a\u3063\u3066\u3069\u3046\u611f\u3058\u307e\u3059\u304b\uff1f\u983b\u5ea6\u306f\u6c7a\u3057\u3066\u9ad8\u304f\u306f\u306a\u3044\u3001\u3080\u3057\u308d\u304b\u306a\u308a\u4f4e\u3044\u3068\u3044\u3046\u5370\u8c61\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\u3002\u305f\u3060\u30d3\u30b9\u30db\u30b9\u30db\u30cd\u30fc\u30c8\u306f\u9aa8\u306b\u5e74\u306e\u5358\u4f4d\u3067\u6c88\u7740\u3059\u308b\u306e\u3067\u3001\u670d\u7528\u304c\u9577\u671f\u306b\u53ca\u3079\u3070\u984e\u9aa8\u58ca\u6b7b\u306e\u30ea\u30b9\u30af\u306f\u5f90\u3005\u306b\u4e0a\u6607\u3057\u307e\u3059\u3002\uff14\u5e74\u4ee5\u4e0a\u306e\u670d\u7528\u3067\u984e\u9aa8\u58ca\u6b7b\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3057\u59cb\u3081\u308b\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002
\n\u3000\u307e\u305f\u3053\u308c\u3089\u306e\u9aa8\u5438\u53ce\u6291\u5236\u5264\u3092\u60aa\u6027\u816b\u760d\u306e\u9aa8\u8ee2\u79fb\uff08\u8ee2\u79fb\u6027\u9aa8\u816b\u760d\uff09\u306b\u5bfe\u3057\u3066\u4f7f\u7528\u3057\u305f\u5834\u5408\u306b\u306f\u3001\u984e\u9aa8\u58ca\u6b7b\u306e\u767a\u751f\u7387\u306f\uff11\uff10\uff10\u500d\u7a0b\u5ea6\u4e0a\u6607\u3059\u308b\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u9aa8\u7c97\u9b06\u75c7\u6cbb\u7642\u306b\u304a\u3051\u308b\u984e\u9aa8\u58ca\u6b7b\u3068\u306f\u533a\u5225\u3057\u3066\u8003\u3048\u308b\u5fc5\u8981\u304c\u3042\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n

1\u5e74\u9593\u3067<\/p>\n

\"\"<\/p>\n<\/dd>\n<\/dl>\n

\n
\n

\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3067\u306f\u984e\u9aa8\u58ca\u6b7b\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/h4>\n<\/dt>\n
\n

\"\"\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u306f\u9aa8\u7c97\u9b06\u75c7\u304c\u3057\u3070\u3057\u3070\u4f75\u767a\u3059\u308b\u306e\u3067\u3001\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u3055\u3093\u306e\u306a\u304b\u306b\u306f\u30d3\u30b9\u30db\u30b9\u30db\u30cd\u30fc\u30c8\u88fd\u5264\u3092\u670d\u7528\u3057\u305f\u308a\u3001\u30c7\u30ce\u30b9\u30de\u30d6\u306e\u76ae\u4e0b\u6ce8\u5c04\u3092\u53d7\u3051\u3066\u3044\u305f\u308a\u3059\u308b\u65b9\u3082\u591a\u304f\u3044\u3089\u3063\u3057\u3083\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u984e\u9aa8\u58ca\u6b7b\u306e\u767a\u75c7\u30fb\u5897\u60aa\u56e0\u5b50\u306b\u306f\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\uff08\u526f\u814e\u76ae\u8cea\u30b9\u30c6\u30ed\u30a4\u30c9\uff09\u88fd\u5264\u306e\u4f7f\u7528\u3068\u53e3\u8154\u5185\u885b\u751f\u74b0\u5883\u306e\u60aa\u5316\u304c\u3042\u308a\u307e\u3059\u3002\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3067\u306f\u553e\u6db2\u5206\u6ccc\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u307e\u305f\u624b\u6307\u306e\u5909\u5f62\u304c\u9032\u884c\u3059\u308c\u3070\u6b6f\u78e8\u304d\u306e\u969b\u306b\u78e8\u304d\u6b8b\u3057\u304c\u751f\u3058\u307e\u3059\u3002\u305d\u306e\u610f\u5473\u3067\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u3055\u3093\u3067\u306f\u901a\u5e38\u306e\u9aa8\u7c97\u9b06\u75c7\u60a3\u8005\u3055\u3093\u306b\u6bd4\u3079\u3066\u3001\u984e\u9aa8\u58ca\u6b7b\u306e\u767a\u75c7\u983b\u5ea6\u304c\u9ad8\u3044\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002\u305f\u3060\u6b8b\u5ff5\u306a\u304c\u3089\u3001\u5177\u4f53\u7684\u306b\u3069\u306e\u304f\u3089\u3044\u984e\u9aa8\u58ca\u6b7b\u306e\u983b\u5ea6\u304c\u9ad8\u307e\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u5b9a\u307e\u3063\u305f\u6570\u5b57\u306f\u51fa\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u307e\u305f\u3001\u764c\u30fb\u9ad8\u9f62\u30fb\u900f\u6790\u3082\u984e\u9aa8\u58ca\u6b7b\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3059\u3002\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u5b9a\u671f\u7684\u306b\u6b6f\u79d1\u5065\u8a3a\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3001\u3068\u308a\u308f\u3051\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u306f\u5927\u5207\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<\/dd>\n<\/dl>\n

\n
\n

\u306a\u305c\u984e\u9aa8\u3060\u3051\u306b\u58ca\u6b7b\u304c\u8d77\u3053\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/h4>\n<\/dt>\n
\n

\"\"\u3082\u3063\u3068\u3082\u306a\u7591\u554f\u3067\u3059\u306d\u3002\u30d3\u30b9\u30db\u30b9\u30db\u30cd\u30fc\u30c8\u3084\u30c7\u30ce\u30b9\u30de\u30d6\u306f\u5168\u8eab\u306e\u9aa8\u306b\u5206\u5e03\u3059\u308b\u306e\u306b\u3001\u306a\u305c\u984e\u9aa8\u3060\u3051\u306b\u58ca\u6b7b\u304c\u8d77\u3053\u308b\u306e\u304b\u3068\u3044\u3046\u8cea\u554f\u3067\u3059\u3002\u3059\u3079\u3066\u306e\u7406\u7531\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u308b\u8a33\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u7406\u7531\u306e\u3072\u3068\u3064\u306f\u984e\u9aa8\u304c\u3055\u3089\u3055\u308c\u3066\u3044\u308b\u74b0\u5883\u3001\u3064\u307e\u308a\u53e3\u8154\u5185\u7d30\u83cc\u306e\u5b58\u5728\u3067\u3059\u3002\u7279\u306b\u629c\u6b6f\u306a\u3069\u306e\u5916\u79d1\u7684\u51e6\u7f6e\u3092\u53d7\u3051\u305f\u5834\u5408\u3001\u984e\u9aa8\u306f\u3053\u306e\u53e3\u8154\u3068\u76f4\u63a5\u4ea4\u901a\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u53e3\u8154\u5185\u885b\u751f\u74b0\u5883\u306e\u60aa\u3055\u304c\u984e\u9aa8\u58ca\u6b7b\u306e\u767a\u75c7\u56e0\u5b50\u30fb\u5897\u60aa\u56e0\u5b50\u3068\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n

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\n
\n

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\n

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\n
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\u984e\u9aa8\u58ca\u6b7b\u306e\u75c7\u72b6\u3068\u6cbb\u7642<\/h4>\n<\/dt>\n
\n

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\n
\n

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\n

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\n\uff12\uff09\u3053\u306e\u5834\u5408\u306e\u300c\u534a\u6e1b\u671f\u304c\uff12\u5e74\uff5e\uff13\u5e74\u300d\u3068\u306f\u300c\u3072\u3068\u305f\u3073\u9aa8\u306b\u6c88\u7740\u3057\u305f\u30d3\u30b9\u30db\u30b9\u30db\u30cd\u30fc\u30c8\u304c\u534a\u5206\u306b\u6e1b\u5c11\u3059\u308b\u307e\u3067\uff12\u5e74\uff5e\uff13\u5e74\u304b\u304b\u308b\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u3059\u3002<\/p>\n<\/dd>\n<\/dl>\n

\n
\n

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\n

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\"\"<\/p>\n<\/dd>\n<\/dl>\n

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