{"id":28,"date":"2023-07-18T18:30:41","date_gmt":"2023-07-18T09:30:41","guid":{"rendered":"http:\/\/aquacurrent.com\/rheuma-net\/securewp\/?page_id=28"},"modified":"2023-12-03T12:13:35","modified_gmt":"2023-12-03T03:13:35","slug":"dtherapy","status":"publish","type":"page","link":"https:\/\/www.rheuma-net.or.jp\/rheuma\/rheuma\/dtherapy\/","title":{"rendered":"\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u6cbb\u7642 &#8211; \u85ac\u7269\u7642\u6cd5"},"content":{"rendered":"<h2>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u6cbb\u7642 &#8211; \u85ac\u7269\u7642\u6cd5<\/h2>\n<p>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u85ac\u7269\u6cbb\u7642\u306e\u57fa\u672c\u65b9\u91dd\uff08\uff12\uff10\uff12\uff13\u5e74\uff09<br \/>\n\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3068\u8a3a\u65ad\u3055\u308c\u305f\u6642\u306b\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u6cbb\u7642\u3092\u884c\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u65e5\u672c\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\u304c\uff12\uff10\uff12\uff10\u5e74\u306b\u307e\u3068\u3081\u305f\u6cbb\u7642\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u3054\u304f\u7c21\u7565\u5316\u3057\u3066\u8aac\u660e\u3057\u307e\u3059\u3002\u65e5\u672c\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u30a2\u30e1\u30ea\u30ab\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\uff08ACR\uff09\u3001\u6b27\u5dde\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\uff08Eular\uff09\u304c\u63d0\u5531\u3057\u305f\u3082\u306e\u306b\u547c\u5fdc\u3057\u3066\u4f5c\u3089\u308c\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-83\" src=\"https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/treatment-phase.png\" alt=\"\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u6cbb\u7642 - \u85ac\u7269\u7642\u6cd5\" width=\"911\" height=\"300\" srcset=\"https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/treatment-phase.png 911w, https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/treatment-phase-300x99.png 300w, https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/treatment-phase-768x253.png 768w, https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/treatment-phase-80x26.png 80w\" sizes=\"(max-width: 911px) 100vw, 911px\" \/><\/p>\n<dl class=\"supplement-accordion\">\n<dt>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32020\u306b\u57fa\u3065\u3044\u305fRA\u6cbb\u7642\u306e\u6982\u8981<\/dt>\n<dd>\n<p>\u65e5\u672c\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\u306b\u3088\u3063\u3066\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u6cbb\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c2020\u5e74\u306b\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u30022023\u5e74\u306b\u306f\u65b0\u3057\u3044\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u767a\u8868\u3055\u308c\u308b\u4e88\u5b9a\u306b\u306f\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u73fe\u6642\u70b9\u3067\u518d\u8a3a\u3067\u3042\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u57fa\u3065\u3044\u3066\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u6cbb\u7642\u306e\u6982\u8981\u3092\u793a\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<br \/>\n\u307e\u305a\u306f\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u8a3a\u65ad\u304c\u3064\u3044\u305f\u3068\u3053\u308d\u3067\u3001\u30d5\u30a7\u30fc\u30ba1\u306e\u6cbb\u7642\u3092\u958b\u59cb\u3057\u307e\u3059\u3002\u307e\u305a\u306f\u3001\u8a3a\u65ad\u3068\u3068\u3082\u306b\u6297\u30ea\u30a6\u30de\u30c1\u85ac\u3001\u7279\u306b\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\uff08MTX\uff09\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-84\" src=\"https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage002.png\" alt=\"\u30d5\u30a7\u30fc\u30ba1\" width=\"698\" height=\"389\" srcset=\"https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage002.png 698w, https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage002-300x167.png 300w, https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage002-80x45.png 80w\" sizes=\"(max-width: 698px) 100vw, 698px\" \/><\/p>\n<p>7.5-15mg\/wk\u306eMTX\u6295\u4e0e\u3067\u3001\u95a2\u7bc0\u708e\u306e\u5e73\u574750\uff05\u7a0b\u5ea6\u306e\u6539\u5584\uff08\u30d7\u30e9\u30bb\u30dc15%\u7a0b\u5ea6\u306e\u6539\u5584\uff09\u3068\u5b89\u5168\u6027\u304c\u793a\u3055\u308c\uff08N Engl J Med 1985; 312:818-822\uff09\u3001\u305d\u306e\u5f8c\u3082\u591a\u304f\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u52b9\u679c\u3068\u5b89\u5168\u6027\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u7c73\u56fd\u304a\u3088\u3073\u6b27\u5dde\u306e\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u3082\u307e\u305a\u8003\u616e\u3059\u3079\u304dAnchor Drug\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u3001\u5730\u57df\u5dee\u306f\u3042\u308a\u307e\u3059\u304c\u65e5\u672c\u3067\u308250\u221270%\u306e\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u3055\u3093\u304cMTX\u306e\u51e6\u65b9\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002<br \/>\nMTX\u304c\u52b9\u679c\u3068\u5b89\u5168\u6027\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u826f\u3044\u85ac\u5264\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3068\u306f\u3044\u3063\u3066\u3082\u3001\u5168\u304f\u526f\u4f5c\u7528\u304c\u306a\u3044\u308f\u3051\u3067\u306f\u3082\u3061\u308d\u3093\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u809d\u969c\u5bb3\u3084\u53e3\u5185\u708e\u306a\u3069\u306e\u6d88\u5316\u5668\u75c7\u72b6\u306f\u8449\u9178\u30921\u22122\u65e5\u5f8c\u306b\u670d\u7528\u3059\u308b\u3053\u3068\u3067\u591a\u304f\u306e\u5834\u5408\u7de9\u548c\u3067\u304d\u307e\u3059\u3002<br \/>\n\u307e\u305f\u3001\u3042\u308b\u7a0b\u5ea6\u4ee5\u4e0a\u306e\u91cf\u3092\u670d\u7528\u3059\u308b\u5834\u5408\u306f\u5438\u53ce\u52b9\u7387\u304c\u4e0b\u304c\u308a\u3001\u5897\u91cf\u3057\u305f\u5206\u306e\u52b9\u679c\u304c\u5f97\u3089\u308c\u306a\u3044\u3053\u3068\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u6700\u8fd1\u90311\u56de\u306e\u76ae\u4e0b\u6ce8\u5c04\u88fd\u5264\u3082\u6b27\u7c73\u306b\u9045\u308c\u306f\u3057\u307e\u3057\u305f\u304c\u65e5\u672c\u3067\u3082\u4f7f\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<br \/>\n\u9ad8\u9f62\u8005\u3067\u306f\u3001MTX\u3088\u308a\u3082\u514d\u75ab\u6291\u5236\u4f5c\u7528\u306e\u5c11\u306a\u3044\u85ac\u5264\u3092\u307e\u305a\u8a66\u3059\u3068\u3044\u3046\u50be\u5411\u3082\u4ee5\u524d\u306f\u3042\u308a\u307e\u3057\u305f\u304c\u3001\u6297CCP\u6297\u4f53\u967d\u6027\u3001\u30ea\u30a6\u30de\u30c8\u30a4\u30c9\u56e0\u5b50\u967d\u6027\u3001\u3059\u3067\u306b\u9aa8\u3073\u3089\u3093\u304c\u59cb\u307e\u3063\u3066\u3044\u308b\u306a\u3069\u306e\u5834\u5408\u306f\u3001\u9ad8\u9f62\u8005\u3067\u3042\u3063\u3066\u3082\u814e\u6a5f\u80fd\u306a\u3069\u306b\u554f\u984c\u304c\u306a\u3051\u308c\u3070\u3001\u7a4d\u6975\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<br \/>\nMTX\u306e\u307f\u3067\u5341\u5206\u306a\u52b9\u679c\u304c\u5f97\u3089\u308c\u306a\u3044\u5834\u5408\u306b\u306f\u3001\u305d\u306e\u4ed6\u306e\u5f93\u6765\u578b\u306e\u6297\u30ea\u30a6\u30de\u30c1\u85ac\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u3001\u4ee3\u8868\u7684\u306a\u3082\u306e\u3068\u3057\u3066\u306f\u30b5\u30e9\u30be\u30b9\u30eb\u30d5\u30a1\u30d4\u30ea\u30b8\u30f3\u3001\u30a4\u30b0\u30e9\u30c1\u30e2\u30c9\u3001\u30d6\u30b7\u30e9\u30df\u30f3\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u307e\u305f\u3001MTX\u304c\u4f7f\u7528\u3067\u304d\u306a\u3044\u5834\u5408\u3082\u307b\u304b\u306e\u6297\u30ea\u30a6\u30de\u30c1\u85ac\u3092\u958b\u59cb\u3057\u307e\u3059\u304c\u3001\u598a\u5a20\u306e\u5e0c\u671b\u304c\u3042\u308b\u5834\u5408\u306f\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u3001\u30b5\u30e9\u30be\u30b9\u30eb\u30d5\u30a1\u30d4\u30ea\u30b8\u30f3\u306a\u3069\u304c\u8003\u616e\u3055\u308c\u307e\u3059\u3002<br \/>\n\u30b9\u30c6\u30ed\u30a4\u30c9\u306b\u95a2\u3057\u3066\u306f\u3001\u9aa8\u7c97\u9b06\u75c7\u3001\u4ee3\u8b1d\u7570\u5e38\uff08\u7cd6\u3001\u8102\u8cea\uff09\u3001\u8840\u5727\u4e0a\u6607\u3001\u611f\u67d3\u75c7\u306a\u3069\u9577\u671f\u306b\u4f7f\u7528\u3057\u305f\u5834\u5408\u306e\u5b89\u5168\u6027\u306b\u61f8\u5ff5\u304c\u3042\u308b\u305f\u3081\u3001\u4f7f\u7528\u3059\u308b\u3068\u3057\u3066\u3082\u521d\u671f\u306b\u3067\u304d\u308b\u3060\u3051\u77ed\u671f\u9593\u306e\u4f7f\u7528\u306b\u7559\u3081\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u9577\u671f\u670d\u7528\u3057\u3066\u3044\u308b\u65b9\u306e\u5834\u5408\u306f\u6025\u306b\u4e2d\u6b62\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u614e\u91cd\u306a\u7ba1\u7406\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\u3002<br \/>\n\u3053\u306e\u3088\u3046\u306a\u6cbb\u7642\u3092\u884c\u3063\u3066\u3082\u6cbb\u7642\u958b\u59cb\u304b\u30893\u30ab\u6708\u3067\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u306a\u3044\u5834\u5408\u3001\u3082\u3057\u304f\u306f6\u30ab\u6708\u3067\u5341\u5206\u306a\u6cbb\u7642\u76ee\u6a19\u306b\u9054\u3057\u3066\u3044\u306a\u3044\u5834\u5408\u306b\u306f\u3001\u30d5\u30a7\u30fc\u30ba2\u306b\u9032\u3080\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-85\" src=\"https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage004.png\" alt=\"\u30d5\u30a7\u30fc\u30ba2\" width=\"697\" height=\"391\" srcset=\"https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage004.png 697w, https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage004-300x168.png 300w, https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage004-80x45.png 80w\" sizes=\"(max-width: 697px) 100vw, 697px\" \/><\/p>\n<p>\u30d5\u30a7\u30fc\u30ba2\u3067\u306f\u3001\u6ce8\u5c04\u85ac\u3067\u3042\u308b\u751f\u7269\u5b66\u7684\u88fd\u5264\uff08TNF\u6291\u5236\u85ac\u3001IL-6\u53d7\u5bb9\u4f53\u6291\u5236\u85ac\u3001T \u7d30\u80de\u6d3b\u6027\u5316\u963b\u5bb3\u85ac\uff09\u3082\u3057\u304f\u306f\u3001\u7d4c\u53e3\u85ac\u306eJAK\u963b\u5bb3\u85ac\u3092\u8ffd\u52a0\u3057\u307e\u3059\u3002\u751f\u7269\u5b66\u7684\u88fd\u5264\u306f\u65e2\u306b\u7d0420\u5e74\u306e\u4f7f\u7528\u7d4c\u9a13\u304c\u3042\u308b\u305f\u3081\u3001JAK\u963b\u5bb3\u85ac\u3088\u308a\u3082\u307e\u305a\u512a\u5148\u3057\u3066\u8003\u616e\u3055\u308c\u308b\u3068\u30012020\u5e74\u767a\u8868\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002MTX\u3092\u4f7f\u7528\u3057\u3066\u3044\u306a\u3044\u5834\u5408\u3082\u540c\u69d8\u3067\u3059\u304c\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u3068\u3057\u3066\u306fMTX\u3068\u4f75\u7528\u3057\u306a\u3044\u3068\u304d\u306e\u30c7\u30fc\u30bf\u304c\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u4f5c\u6210\u6642\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u305fIL-6\u53d7\u5bb9\u4f53\u6291\u5236\u85ac\u3001T \u7d30\u80de\u6d3b\u6027\u5316\u963b\u5bb3\u85ac\u304c\u3001TNF\u963b\u5bb3\u85ac\u3088\u308a\u3082\u512a\u5148\u3055\u308c\u308b\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u30d5\u30a7\u30fc\u30ba2\u3067\u30823\u30ab\u6708\u3067\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u306a\u3044\u5834\u5408\u3001\u3082\u3057\u304f\u306f6\u30ab\u6708\u3067\u5341\u5206\u306a\u6cbb\u7642\u76ee\u6a19\u306b\u9054\u3057\u3066\u3044\u306a\u3044\u5834\u5408\u3001\u307e\u305f\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u6d3b\u52d5\u6027\u304c\u518d\u71c3\u3057\u305f\u5834\u5408\u306f\u30d5\u30a7\u30fc\u30ba3\u306b\u9032\u3080\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<br \/>\n\u30d5\u30a7\u30fc\u30ba3\u3067\u306f\u751f\u7269\u5b66\u7684\u88fd\u5264\u3082\u3057\u304f\u306fJAK\u963b\u5bb3\u85ac\u306e\u4e2d\u304b\u3089\u4ed6\u306e\u3082\u306e\u306b\u5909\u66f4\u3057\u307e\u3059\u304c\u3001\u30d5\u30a7\u30fc\u30ba\uff12\u3067TNF\u963b\u5bb3\u85ac\u3092\u4f7f\u7528\u3057\u3066\u3044\u305f\u5834\u5408\u306b\u306f\u3001TNF\u963b\u5bb3\u85ac\u4ee5\u5916\u306e\u9078\u629e\u80a2\u7d4c\u306e\u5207\u308a\u66ff\u3048\u3092\u512a\u5148\u3057\u3066\u8003\u616e\u3057\u307e\u3059\u3002<br \/>\n\u307e\u305f\u3001\u9577\u671f\u9593\u6cbb\u7642\u76ee\u6a19\u3092\u9054\u6210\u3057\u3066\u304b\u3089\u7dad\u6301\u3067\u304d\u305f\u5834\u5408\u306b\u306f\u3001\u6cbb\u7642\u85ac\u306e\u6e1b\u91cf\u3092\u8003\u616e\u3057\u307e\u3059\u3002<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-86\" src=\"https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage006.png\" alt=\"\u30d5\u30a7\u30fc\u30ba3\" width=\"697\" height=\"392\" srcset=\"https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage006.png 697w, https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage006-300x169.png 300w, https:\/\/www.rheuma-net.or.jp\/rheuma\/securewp\/wp-content\/uploads\/2023\/07\/tr_dtimage006-80x45.png 80w\" sizes=\"(max-width: 697px) 100vw, 697px\" \/><\/p>\n<p style=\"text-align: right;\">\u4ee4\u548c5\u5e741\u6708\u66f4\u65b0<\/p>\n<\/dd>\n<\/dl>\n<h3>\u57fa\u672c\u7684\u6cbb\u7642<\/h3>\n<h4>\u7b2c1\u30d5\u30a7\u30fc\u30ba<\/h4>\n<p>\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\uff08MTX\uff1b\u30ea\u30a6\u30de\u30c8\u30ec\u30c3\u30af\u30b9\u3001\u30e1\u30c8\u30ec\u30fc\u30c8\u3001\u30e1\u30c8\u30b8\u30a7\u30af\u30c8\u306a\u3069\uff09<br \/>\nMTX\u3092\u5e74\u9f62\u3084\u4f53\u91cd\u306a\u3069\u304b\u3089\u8003\u3048\u3066\uff14mg\u304b\u308916\uff4d\uff47\u306e\u9593\u3067\u4f7f\u7528\u3057\u307e\u3059\u3002\u539f\u5247\u3068\u3057\u30666\u304b\u6708\u4ee5\u5185\u306b\u6cbb\u7642\u76ee\u6a19\u3092\u9054\u6210\u3067\u304d\u306a\u3044\u6642\u306b\u306f\u7b2c\uff12\u30d5\u30a7\u30fc\u30ba\u306b\u9032\u307f\u307e\u3059\u3002\u6cbb\u7642\u958b\u59cb\u5f8c3\u30f6\u6708\u3067\u6539\u5584\u304c\u306a\u3051\u308c\u3070\u6cbb\u7642\u3092\u898b\u76f4\u3057\u307e\u3059\u3002\u3053\u3053\u3067\u306e\u6cbb\u7642\u76ee\u6a19\u3068\u306f\u5bdb\u89e3\u3001\u3042\u308b\u3044\u306f\u4f4e\u75be\u60a3\u6d3b\u52d5\u6027\u306e\u72b6\u614b\u306b\u6291\u3048\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4>\u7b2c2\u30d5\u30a7\u30fc\u30ba<\/h4>\n<p>\u751f\u7269\u5b66\u7684\u88fd\u5264\uff08\u30d0\u30a4\u30aa\u88fd\u5264\uff1b\u6ce8\u5c04\uff09\u3001\u3042\u308b\u3044\u306fJAK\u963b\u5bb3\u85ac\uff08\u5185\u670d\uff09\u306bMTX\u3092\u4f75\u7528\u3001\u3042\u308b\u3044\u306f\u5358\u72ec\u3067\u4f7f\u7528\u3057\u307e\u3059\u3002\u5b89\u5168\u6027\u3092\u8003\u3048\u3066\u901a\u5e38\u306f\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092\u512a\u5148\u3057\u307e\u3059\u3002<\/p>\n<h4>\u7b2c3\u30d5\u30a7\u30fc\u30ba<\/h4>\n<p>\u306f\u3058\u3081\u306b\u4f7f\u7528\u3057\u305f\u751f\u7269\u5b66\u7684\u88fd\u5264\u3001JAK\u963b\u5bb3\u85ac\u3067\u52b9\u679c\u304c\u898b\u3089\u308c\u306a\u3044\u5834\u5408\u3001\u4ed6\u306e\u751f\u7269\u5b66\u7684\u88fd\u5264\u3001JAK\u963b\u5bb3\u85ac\u3078\u306e\u5909\u66f4\u3092\u8003\u3048\u307e\u3059\u3002TNF\u963b\u5bb3\u85ac\u3067\u52b9\u679c\u304c\u4e0d\u5341\u5206\u306a\u5834\u5408\u306f\u975eTNF\u963b\u5bb3\u85ac\u3078\u306e\u5207\u308a\u66ff\u3048\u3092\u512a\u5148\u3057\u307e\u3059\u3002<\/p>\n<h4>\u88dc\u5b8c\u7684\u6cbb\u7642<\/h4>\n<ol>\n<li>MTX\u304c\u526f\u4f5c\u7528\u306a\u3069\u3067\u4f7f\u3048\u306a\u3044\u5834\u5408\u306b\u306f\u3001\u4ee5\u524d\u304b\u3089\u4f7f\u308f\u308c\u3066\u304d\u305f\u6297\u30ea\u30a6\u30de\u30c1\u85ac\u3001\u30b9\u30c6\u30ed\u30a4\uff84\uff9e\uff08\u30df\u30cd\u30e9\u30eb\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u88fd\u5264\uff1b\u30d7\u30ec\u30c9\u30cb\u30f3\u306a\u3069\uff09\u3092\u4ee3\u308f\u308a\u306b\u3001\u3042\u308b\u3044\u306f\u4f75\u7528\u3057\u3066\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<li>\u75bc\u75db\u3092\u3068\u308b\u305f\u3081\u306b\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6d88\u708e\u5264\uff08NSAIDs\uff1a\u30ed\u30ad\u30bd\u30cb\u30f3\u3001\u30dc\u30eb\u30bf\u30ec\u30f3\u306a\u3069\uff09\u3092\u52a0\u3048\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<li>\u9aa8\u7c97\u9b06\u75c7\u306e\u4e88\u9632\u30fb\u6cbb\u7642\u306e\u305f\u3081\u306b\u6297\u30e9\u30f3\u30af\u30eb\u6297\u4f53\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ol>\n<h3>\u75be\u60a3\u6d3b\u52d5\u6027\u3068\u306f<\/h3>\n<p>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306b\u304a\u3044\u3066\u3001\u75be\u60a3\u6d3b\u52d5\u6027\u3068\u306f\u81ea\u899a\u75c7\u72b6\uff08\u60a3\u8005\u3055\u3093\u306e\u611f\u3058\u308b\u95a2\u7bc0\u306e\u75db\u3055\uff1dVAS\uff09\u306e\u7a0b\u5ea6\u3001\u816b\u308c\u3068\u5727\u75db\uff08\u62bc\u3055\u308c\u3066\u75db\u3044\u3053\u3068\uff09\u306e\u3042\u308b\u95a2\u7bc0\u6570\u3001\u708e\u75c7\u3092\u793a\u3059\u691c\u67fb\uff08\u8d64\u6c88\uff08\u8840\u6c88\uff09\u3042\u308b\u3044\u306fCRP\uff09\u306e\u6570\u5024\u306a\u3069\u306b\u3088\u308a\u6c7a\u5b9a\u3057\u307e\u3059\u3002\u3044\u304f\u3064\u304b\u306e\u8a55\u4fa1\u6cd5\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3088\u304f\u4f7f\u308f\u308c\u3066\u3044\u308b\u306e\u306fDAS28\u3068\u3044\u3046\u8a55\u4fa1\u6cd5\u3067\u3053\u308c\u306f\u81ea\u899a\u75c7\u72b6\u300128\u306e\u95a2\u7bc0\u6570\u306e\u72b6\u614b\u3068\u691c\u67fb\u5024\u304b\u3089\u8a08\u7b97\u3057\u307e\u3059\u3002\u9ad8\u75be\u60a3\u6d3b\u52d5\u6027\u3001\u4e2d\u7b49\u5ea6\u75be\u60a3\u6d3b\u52d5\u6027\u3001\u4f4e\u75be\u60a3\u6d3b\u52d5\u6027\u3001\u5bdb\u89e3\u306b\u5206\u3051\u3089\u308c\u307e\u3059\u3002<br \/>\n\u5bdb\u89e3\u3068\u306f\u307b\u3068\u3093\u3069\u81ea\u899a\u7684\u306a\u75c7\u72b6\u304c\u306a\u304f\u306a\u308b\u3068\u3068\u3082\u306b\u3001\u8a3a\u5bdf\u3067\u3082\u691c\u67fb\u3067\u3082\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u6d3b\u52d5\u6027\u304c\u505c\u6b62\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u72b6\u614b\u3067\u3059\u3002DAS28\u306e\u8a08\u7b97\u3067\u306f2.3\u672a\u6e80\u306b\u5f53\u305f\u308a\u307e\u3059\u3002<br \/>\n\u4f4e\u75be\u60a3\u6d3b\u52d5\u6027\u3068\u306f\u8efd\u5ea6\u306e\u75c7\u72b6\u304c\u898b\u3089\u308c\u308b\u304b\u3001CRP\u304c\u5c11\u3057\u4e0a\u304c\u3063\u305f\u72b6\u614b\u3067DAS28\u3067\u306f2.3\u4ee5\u4e0a2.7\u672a\u6e80\u3067\u3059\u3002<\/p>\n<h3>\u85ac\u7269\u7642\u6cd5\u306b\u4f7f\u7528\u3055\u308c\u308b\u85ac\u5264\u3064\u3044\u3066<\/h3>\n<ul>\n<li><a href=\"mtx\/\">\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8<\/a><\/li>\n<li><a href=\"biologics\/\">\u751f\u7269\u5b66\u7684\u88fd\u5264\u30fbBS<\/a><\/li>\n<li><a href=\"jak\/\">JAK\u963b\u5bb3\u85ac<\/a><\/li>\n<li><a href=\"dmard\/\">\u6297\u30ea\u30a6\u30de\u30c1\u85ac<\/a><\/li>\n<li><a href=\"steroid\/\">\u30b9\u30c6\u30ed\u30a4\u30c9<\/a><\/li>\n<li><a href=\"nsaids\/\">\u975e\u30b9\u30c6\u30ed\u30a4\u30c9<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u6cbb\u7642 &#8211; \u85ac\u7269\u7642\u6cd5 \u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u85ac\u7269\u6cbb\u7642\u306e\u57fa\u672c\u65b9\u91dd\uff08\uff12\uff10\uff12\uff13\u5e74\uff09 \u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3068\u8a3a\u65ad\u3055\u308c\u305f\u6642\u306b\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u6cbb\u7642\u3092\u884c\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u65e5\u672c\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\u304c\uff12\uff10\uff12\uff10\u5e74\u306b\u307e\u3068\u3081\u305f\u6cbb\u7642\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u3054\u2026<a href=\"https:\/\/www.rheuma-net.or.jp\/rheuma\/rheuma\/dtherapy\/\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":20,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/www.rheuma-net.or.jp\/rheuma\/wp-json\/wp\/v2\/pages\/28"}],"collection":[{"href":"https:\/\/www.rheuma-net.or.jp\/rheuma\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.rheuma-net.or.jp\/rheuma\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.rheuma-net.or.jp\/rheuma\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rheuma-net.or.jp\/rheuma\/wp-json\/wp\/v2\/comments?post=28"}],"version-history":[{"count":10,"href":"https:\/\/www.rheuma-net.or.jp\/rheuma\/wp-json\/wp\/v2\/pages\/28\/revisions"}],"predecessor-version":[{"id":12257,"href":"https:\/\/www.rheuma-net.or.jp\/rheuma\/wp-json\/wp\/v2\/pages\/28\/revisions\/12257"}],"up":[{"embeddable":true,"href":"https:\/\/www.rheuma-net.or.jp\/rheuma\/wp-json\/wp\/v2\/pages\/20"}],"wp:attachment":[{"href":"https:\/\/www.rheuma-net.or.jp\/rheuma\/wp-json\/wp\/v2\/media?parent=28"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}